Description

3-(4-Methoxyphenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated aromatic ketone building block. This compound is prized for its trifluoromethyl ketone moiety, which is a critical pharmacophore in medicinal chemistry and agrochemical design. It serves as a versatile intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine for enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Intermediate for creating fluorinated polymers and liquid crystals with unique thermal and optical properties.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and inhibitors for studying enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a 4-methoxyphenyl-trifluoroacetone motif.

Basic Information

Product Name	3-(4-Methoxyphenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	22102-10-9
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	1-(4-Methoxyphenyl)-3,3,3-trifluoro-1-propanone; 4-Methoxyphenyl Trifluoroacetone; 4'-Methoxy-3,3,3-trifluoropropiophenone; 3,3,3-Trifluoro-1-(4-methoxyphenyl)-1-propanone; 4-Methoxy-α,α,α-trifluoropropiophenone; p-Methoxyphenyl Trifluoroacetone; TFMP; 22102-10-9
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. We provide comprehensive analytical data including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. Certificates of Analysis (COA) are available upon request for every batch, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.