Description

1-(2-Fluorophenyl)Butan-1-One is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the fluorine atom at the ortho position of the phenyl ring, which can dramatically influence the electronic properties and metabolic stability of final compounds. This makes it a critical intermediate for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, due to the fluorine atom's ability to enhance blood-brain barrier penetration and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorophenyl moiety can improve biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals, where the fluorine group modifies thermal stability and optical properties.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	1-(2-Fluorophenyl)Butan-1-One
CAS No.	21550-03-8
Molecular Formula	C₁₀H₁₁FO
Molecular Weight	166.19 g/mol
Synonyms	2'-Fluorobutyrophenone; 1-Butanone, 1-(2-fluorophenyl)-; 2-Fluorobutyrophenone; o-Fluorobutyrophenone; 1-(2-Fluorophenyl)-1-butanone; Butyrophenone, 2'-fluoro-; 2-Fluorophenyl propyl ketone; NSC 403796
EINECS	Contact for details

Quality Control

Our 1-(2-Fluorophenyl)Butan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your R&D and scale-up activities. Our quality commitment ensures material consistency and traceability for your critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.