Description

12-Deoxyerythromycin 3''-n-Oxide is a key chemical intermediate derived from the erythromycin macrolide antibiotic structure. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel semi-synthetic antibiotics and for studying structure-activity relationships. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of advanced antibacterial agents and chemical probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel macrolide antibiotics and derivatives.
• Research & Development: Used in academic and industrial laboratories for pharmacological and microbiological studies.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying the erythromycin core to explore new biological activities and reduce bacterial resistance.
• Process Chemistry: Employed in scaling up synthetic routes for potential new drug candidates.

Basic Information

Product Name	12-Deoxyerythromycin 3''-n-Oxide
CAS No.	21395-58-4
Molecular Formula	C37H67NO13
Molecular Weight	733.93 g/mol
Synonyms	12-Deoxyerythromycin 3''-N-oxide; Erythromycin 12-deoxy, 3''-N-oxide; 3''-N-Oxide of 12-deoxyerythromycin; 12-Deoxyerythromycin 3''-amine oxide; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione 3''-oxide
EINECS	Contact for details

Quality Control

Our 12-Deoxyerythromycin 3''-n-Oxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.