Description

(1R)-6,11-Dioxo-2-Ethyl-1,2,3,4,6,11-Hexahydro-2α,5,7-Trihydroxy-1β-Naphthacenecarboxylic Acid Methyl Ester is a complex, stereochemically defined tetracycline derivative with significant synthetic and research utility. This compound matters as a key chiral intermediate or precursor in the development of novel antibiotics and other pharmacologically active molecules. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity building block for advanced synthesis projects, particularly those focused on next-generation tetracycline-class agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel tetracycline antibiotics and analogs.
• Chemical Synthesis: Used in advanced organic synthesis for constructing complex polycyclic frameworks with specific stereochemistry.
• Biochemical Research: Serves as a reference standard or probe molecule in studies of antibiotic mechanism of action and bacterial resistance.
• Process Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) within the tetracycline family.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and methodology development.

Basic Information

Product Name	(1R)-6,11-Dioxo-2-Ethyl-1,2,3,4,6,11-Hexahydro-2α,5,7-Trihydroxy-1β-Naphthacenecarboxylic Acid Methyl Ester
CAS No.	21179-19-1
Molecular Formula	C24H26O8
Molecular Weight	442.46 g/mol
Synonyms	Methyl (1R,2S,4S)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxylate; 2-Ethyl-1,2,3,4,6,11-hexahydro-2α,5,7-trihydroxy-1β-naphthacenecarboxylic acid methyl ester, (1R)-6,11-dioxo-; (1R)-6,11-Dioxo-2-ethyl-1,2,3,4,6,11-hexahydro-2α,5,7-trihydroxy-1β-naphthacenecarboxylic acid methyl ester; A derivative of Tetracycline.
EINECS	Contact for details

Quality Control

Our (1R)-6,11-Dioxo-2-Ethyl-1,2,3,4,6,11-Hexahydro-2α,5,7-Trihydroxy-1β-Naphthacenecarboxylic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to Orange Crystalline Powder
Identification (IR)	Conforms to Reference Spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.