Description

[1R,4R,(+)]-1β,4β-Methano-1,2,3,4-Tetrahydronaphthalene-2-One is a high-purity, chiral bicyclic ketone of significant synthetic interest. This compound serves as a versatile and valuable chiral building block for the construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of prostaglandins, terpenoids, and other bioactive molecules.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Fragrance and Flavor Chemistry: Serves as a starting material for the synthesis of complex odorants and flavor compounds with specific stereochemistry.
• Material Science Research: Employed in the development of chiral polymers or liquid crystals where the rigid bicyclic structure imparts specific properties.
• Organic Methodology Development: Used as a standard or model substrate for testing new synthetic transformations and catalysts.

Basic Information

Product Name	[1R,4R,(+)]-1β,4β-Methano-1,2,3,4-Tetrahydronaphthalene-2-One
CAS No.	21159-73-9
Molecular Formula	C₁₁H₁₂O
Molecular Weight	160.21 g/mol
Synonyms	(+)-(1R,4R)-1,4-Methano-1,2,3,4-tetrahydronaphthalen-2-one; (1R,4R)-1,4-Methano-1,2,3,4-tetrahydronaphthalene-2-one; (+)-1,4-Methano-1,2,3,4-tetrahydronaphthalen-2-one; (1R,4R)-1,4-Methanonaphthalen-2(1H)-one; NSC 334365; Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 1,2,3,4-tetrahydro- (related structure)
EINECS	Contact for details

Quality Control

Our [1R,4R,(+)]-1β,4β-Methano-1,2,3,4-Tetrahydronaphthalene-2-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.