Description

3-Formyl-5-Nitro-2-Thiopheneboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a formyl group, a nitro group, and a boronic acid moiety on a thiophene scaffold, makes it an exceptionally versatile reagent for constructing complex heterocyclic systems. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients through cross-coupling reactions and other advanced synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for constructing complex thiophene-based heterocycles via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific thiophene backbones for bioactivity.
• Material Science & OLED Development: Serves as a building block for creating advanced organic electronic materials, including charge-transport layers and emissive materials in organic light-emitting diodes (OLEDs).
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized bidentate or tridentate ligands used in homogeneous catalysis.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and sensors that leverage the boronic acid group's affinity for diols.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of functional polymers with tailored properties.

Basic Information

Product Name	3-Formyl-5-Nitro-2-Thiopheneboronic Acid
CAS No.	21157-02-8
Molecular Formula	C5H4BNO5S
Molecular Weight	200.97 g/mol
Synonyms	(5-Nitro-3-thienylboronic acid)carboxaldehyde; 5-Nitro-3-thiophenecarboxaldehydebronic acid; 3-Formyl-5-nitrothiophene-2-boronic acid; 2-Borono-5-nitro-3-thiophenecarboxaldehyde; 5-Nitro-3-formylthiophene-2-boronic acid; 3-Formyl-5-nitrothiophen-2-ylboronic acid; 2-(5-Nitro-3-formylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (protected form).
EINECS	Contact for details

Quality Control

Every batch of 3-Formyl-5-Nitro-2-Thiopheneboronic Acid undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and commercial synthesis. Our quality assurance protocol includes multiple orthogonal methods to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.