Description

1,2:3,5-Di-o-Isopropylidene-α-D-Xylofuranose is a high-purity, protected sugar derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block and intermediate in the production of complex nucleoside analogs and other biologically active molecules. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in carbohydrate chemistry and antiviral drug development.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of nucleoside-based antiviral and anticancer agents.
• Carbohydrate Chemistry Research: Used as a protected xylofuranose derivative for studying glycosylation reactions and synthesizing complex oligosaccharides.
• Fine Chemical Synthesis: Serves as a versatile building block for creating specialty chemicals with specific stereochemistry.
• Nucleoside Analog Development: Critical for constructing the sugar moiety in modified nucleosides for therapeutic applications.
• Process Chemistry: Employed in scale-up and optimization of routes to active pharmaceutical ingredients (APIs).
• Bioconjugate Chemistry: Can be utilized to introduce carbohydrate motifs into larger biomolecules or materials.

Basic Information

Product Name	1,2:3,5-Di-o-Isopropylidene-α-D-Xylofuranose
CAS No.	20881-04-3
Molecular Formula	C11H18O5
Molecular Weight	230.26 g/mol
Synonyms	1,2:3,5-Di-O-isopropylidene-α-D-xylofuranose; 1,2:3,5-Di-O-(1-methylethylidene)-α-D-xylofuranose; α-D-Xylofuranose, 1,2:3,5-di-O-isopropylidene-; Diisopropylidene-D-xylofuranose; D-Xylose Diacetone Derivative; 1,2-O-Isopropylidene-3,5-O-isopropylidene-α-D-xylofuranose; Acetone D-Xylose Derivative
EINECS	244-095-9

Quality Control

Our 1,2:3,5-Di-o-Isopropylidene-α-D-Xylofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-15° to -19° (c=1 in CHCl3)
Melting Point	78°C - 82°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.