Description

Protoaescigenin is a bioactive triterpenoid saponin aglycone derived from the horse chestnut tree (*Aesculus hippocastanum*). This high-purity reference standard is critical for analytical research and pharmaceutical development, offering a reliable benchmark for quality control and biological activity studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and phytochemical industries for method validation, compound identification, and as a precursor in synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of escin-based APIs and finished products.
• Bioactivity Research: Serves as a key intermediate in studies investigating the anti-inflammatory, anti-edema, and venotonic properties of aescin compounds.
• Phytochemical Analysis: Essential for the qualitative and quantitative HPLC/LC-MS analysis of horse chestnut extracts and related botanical preparations.
• Nutraceutical Development: Employed in the standardization and potency testing of dietary supplements targeting vascular health.
• Chemical Synthesis: Acts as a strategic starting material or intermediate for the semi-synthesis of novel saponin derivatives with enhanced therapeutic profiles.

Basic Information

Product Name	Protoaescigenin
CAS No.	20853-07-0
Molecular Formula	C30H48O5
Molecular Weight	488.70 g/mol
Synonyms	Protoescigenin; 21β,22α-Dihydroxy-3-oxoolean-12-en-28-oic acid; Barringtogenol C; Escigenin; Aescin aglycone; Aescigenin aglycon; (3β,16α,21β,22α)-21,22-Dihydroxy-16-(hydroxymethyl)olean-12-ene-3,23,28-triol
EINECS	Contact for details

Quality Control

Our Protoaescigenin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.