Description

(E)-2-Cyano-3-Phenyl-2-Butenoic Acid CAS NO 20374-54-3 is a high-purity, unsaturated cyano acid derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique α,β-unsaturated nitrile-acid structure makes it a valuable precursor for constructing complex heterocycles and functionalized molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting inflammation, cancer, and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the manufacture of dyes, pigments, and other performance chemicals requiring specific molecular architectures.
• Academic & Industrial Research: A valuable tool for methodological studies in organic chemistry, including cycloaddition and conjugate addition reactions.
• Material Science Precursor: Investigated for use in synthesizing monomers for specialty polymers with tailored properties.

Basic Information

Product Name	(E)-2-Cyano-3-Phenyl-2-Butenoic Acid
CAS No.	20374-54-3
Molecular Formula	C11H9NO2
Molecular Weight	187.20 g/mol
Synonyms	(E)-2-Cyano-3-phenylbut-2-enoic acid; trans-2-Cyano-3-phenyl-2-butenoic acid; α-Cyano-β-methylcinnamic acid; 2-Cyano-3-phenyl-2-butenoic acid; (E)-α-Cyano-β-methylcinnamic acid; 2-Butenoic acid, 2-cyano-3-phenyl-, (E)-; (2E)-2-Cyano-3-phenyl-2-butenoic acid
EINECS	Contact for details

Quality Control

Our (E)-2-Cyano-3-Phenyl-2-Butenoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.