Description

Triethyl 4-Phosphonocrotonatedisc 6/01 is a high-purity organophosphorus compound, specifically a triethyl phosphonoacetate derivative, widely used as a key synthetic intermediate. Its primary value lies in its role as a versatile building block in the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient synthesis of α,β-unsaturated esters and other complex organic frameworks. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing olefin linkages in drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators that require specific alkene structures.
• Fine Chemical Production: Serves as a pivotal building block for synthesizing flavors, fragrances, and specialty chemicals.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials via controlled olefination reactions.
• Academic & Industrial R&D: A staple reagent in organic synthesis laboratories for method development and constructing complex molecular architectures.
• Custom Synthesis: Provides a reliable starting point for contract research and manufacturing organizations (CROs/CMOs) executing custom synthesis projects.

Basic Information

Product Name	Triethyl 4-Phosphonocrotonatedisc 6/01
CAS No.	20345-62-4
Molecular Formula	C10H19O5P
Molecular Weight	250.23 g/mol
Synonyms	Triethyl (E)-4-phosphonocrotonate; Triethyl 4-phosphonocrotonate; (E)-Triethyl 4-phosphonobut-2-enoate; Diethyl [(1E)-3-ethoxy-1-methyl-3-oxoprop-1-en-1-yl]phosphonate; (E)-Diethyl (3-ethoxy-1-methyl-3-oxo-1-propenyl)phosphonate; Crotonic acid, 4-phosphono-, triethyl ester; A phosphonate reagent for HWE olefination.
EINECS	Contact for details

Quality Control

Our Triethyl 4-Phosphonocrotonatedisc 6/01 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (by NMR or HPLC), isomeric purity, and impurity profiles. We support compliance with relevant guidelines for use in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E-isomer)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.