Description

Trimethyl(2,3,5,6-Tetrafluorophenyl)Silane is a specialized organosilicon compound featuring a perfluorinated aromatic ring, making it a valuable reagent in advanced synthetic chemistry. Its core value lies in its dual functionality, serving as both a robust silyl protecting group and a versatile building block for introducing fluorinated aromatic units into complex molecular architectures. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, leveraging the unique electronic and metabolic properties of the tetrafluorophenyl group.
• Agrochemical Synthesis: Used to create advanced, fluorinated active ingredients for crop protection agents, enhancing their biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Silylating Agent: Acts as an effective reagent for introducing the trimethylsilyl (TMS) protecting group onto alcohols, phenols, and carboxylic acids under mild conditions.
• Ligand Synthesis: Employed in the preparation of fluorinated ligands for catalysis, particularly in cross-coupling and asymmetric synthesis.
• Organic Synthesis Reagent: A versatile reagent for nucleophilic aromatic substitution (SNAr) and other reactions where a fluorinated aryl silane is required.

Basic Information

Product Name	Trimethyl(2,3,5,6-Tetrafluorophenyl)Silane
CAS No.	20083-07-2
Molecular Formula	C9H10F4Si
Molecular Weight	222.26 g/mol
Synonyms	(2,3,5,6-Tetrafluorophenyl)trimethylsilane; Trimethyl(2,3,5,6-tetrafluorophenyl)silane; Silane, trimethyl(2,3,5,6-tetrafluorophenyl)-; (Perfluoro-p-phenylene)trimethylsilane; TMS-Tetrafluorobenzene; 1-Trimethylsilyl-2,3,5,6-tetrafluorobenzene; 2,3,5,6-Tetrafluorophenyltrimethylsilane
EINECS	Contact for details

Quality Control

Our Trimethyl(2,3,5,6-Tetrafluorophenyl)Silane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.