Description

5,5,5-Trifluoro-Dl-Leucine is a non-natural, fluorinated amino acid derivative of leucine, characterized by the substitution of three fluorine atoms on the terminal methyl group. This structural modification significantly alters its physicochemical properties, making it a valuable building block for advanced research and development. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical sectors. The compound serves as a critical intermediate for creating novel bioactive molecules with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated peptide-based drugs, protease inhibitors, and other bioactive compounds where enhanced metabolic stability is desired.
• Agrochemical Research: Used in the synthesis of novel fluorinated pesticides and herbicides, leveraging the fluorine atom's ability to improve membrane permeability and biological activity.
• Proteomics & Biochemistry: Employed as a stable isotope-labeled analog or a mechanistic probe in metabolic pathway studies and protein interaction research.
• Material Science: Serves as a precursor for specialty polymers and coatings, where the introduction of fluorine can impart unique surface properties and chemical resistance.
• Positron Emission Tomography (PET) Tracer Development: Acts as a precursor for synthesizing F-18 labeled radiopharmaceuticals for diagnostic imaging.

Basic Information

Product Name	5,5,5-Trifluoro-Dl-Leucine
CAS No.	2792-72-5
Molecular Formula	C6H10F3NO2
Molecular Weight	185.15 g/mol
Synonyms	DL-5,5,5-Trifluoroleucine; (±)-5,5,5-Trifluoroleucine; 2-Amino-5,5,5-trifluoro-4-methylpentanoic acid; 5,5,5-Trifluoro-DL-leucine; 5,5,5-Trifluoroleucine; 4-Methyl-5,5,5-trifluoronorvaline; (RS)-5,5,5-Trifluoroleucine; NSC 334916
EINECS	220-531-6

Quality Control

Our 5,5,5-Trifluoro-Dl-Leucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.