Description

6-Methoxy-2-Acetyl Naphthalene is a high-purity aromatic ketone derivative widely employed as a key synthetic intermediate in fine chemical and pharmaceutical manufacturing. Its structural features—methoxy substitution at the 6-position and acetyl functionality at the 2-position of the naphthalene ring—confer enhanced reactivity and selectivity in electrophilic substitutions, condensations, and heterocycle formations. This compound is critically valued by R&D chemists and process engineers developing nonsteroidal anti-inflammatory drugs (NSAIDs), agrochemical actives, and advanced dyes. Global manufacturers rely on consistent, traceable batches of 6-Methoxy-2-Acetyl Naphthalene CAS NO 2700-47-2 to ensure reproducible yields and regulatory compliance across scale-up and cGMP production.

Application

• Synthetic intermediate for naproxen and related propionic acid-class NSAIDs
• Building block in the preparation of naphthoxazine and quinoline-based antifungal agents
• Key precursor in the synthesis of photoactive naphthalene-derived dyes and fluorescent probes
• Reagent in Friedel–Crafts acylation and Claisen rearrangement sequences for specialty polymer modifiers
• Component in high-performance liquid crystal (LC) monomer development for display technologies
• Intermediate for UV-absorbing stabilizers used in automotive coatings and plastics
• Substrate for catalytic asymmetric hydrogenation studies in academic and industrial medicinal chemistry labs

Basic Information

Product Name	6-Methoxy-2-Acetyl Naphthalene
CAS No.	2700-47-2
Molecular Formula	C13H12O2
Molecular Weight	200.23 g/mol
Synonyms	6-Methoxy-2-acetylnaphthalene; 2-Acetyl-6-methoxynaphthalene; 6-Methoxy-β-naphthyl methyl ketone; 6-Methoxy-2-naphthyl methyl ketone; 6-Methoxy-2-acetonaphthone; NSC 65484; 2-(6-Methoxynaphthalen-2-yl)ethanone; 6-Methoxy-2-acetonaphthalene
EINECS	220-279-7

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time), assay (HPLC), residual solvents (GC), heavy metals (USP & ICH Q3D), and organic impurities (HPLC with forced degradation). Manufacturing adheres to ISO 9001:2015 and supports compliance with REACH, FDA 21 CFR Part 113, and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Keep away from strong oxidizing agents and incompatible materials such as strong acids or strong alkalis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Characteristic mild aromatic odor
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 99.0%
Melting Point	82–86°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.