Description

1-Bromo-3,4,5-Trimethoxybenzene is a versatile brominated aromatic building block characterized by its three methoxy substituents, which significantly influence its reactivity and solubility profile. This compound is valued for its role as a key intermediate in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those with complex aromatic or heterocyclic structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators where the trimethoxyphenyl moiety is a key pharmacophore.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers due to its electron-donating methoxy groups.
• Chemical Biology Probes: Useful for incorporating a bromine "handle" into molecules for further functionalization via click chemistry or palladium catalysis in probe development.

Basic Information

Product Name	1-Bromo-3,4,5-Trimethoxybenzene
CAS No.	2675-79-8
Molecular Formula	C9H11BrO3
Molecular Weight	247.09 g/mol
Synonyms	3,4,5-Trimethoxybromobenzene; 3-Bromo-1,2,4-trimethoxybenzene; 3,4,5-Trimethoxyphenyl bromide; Bromomesitylene ether (3,4,5-Trimethoxy); Benzene, 1-bromo-3,4,5-trimethoxy-
EINECS	Contact for details

Quality Control

Our 1-Bromo-3,4,5-Trimethoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	74 - 78 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.