Description

3-(Triethylsilyl)-2-Propyn-1-Ol is a specialized organosilicon building block featuring both a silyl-protected alkyne and a reactive hydroxyl group. This bifunctional nature makes it a valuable intermediate for constructing complex molecular architectures in advanced organic synthesis. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions, click chemistry, and polymer modification.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for introducing alkyne handles for bioconjugation via click chemistry (e.g., CuAAC).
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the triethylsilyl group can act as a protective moiety for alkynes during multi-step syntheses.
• Material Science & Polymer Chemistry: Employed as a monomer or cross-linking agent for creating specialty polymers, silicones, and advanced materials with tailored properties.
• Organic Synthesis Building Block: A versatile reagent for Sonogashira coupling and other palladium-catalyzed reactions to construct complex organic molecules and natural product analogs.
• Ligand & Catalyst Development: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Surface Modification: The reactive groups allow for functionalizing surfaces (e.g., silicon wafers, nanoparticles) to alter wettability, adhesion, or biocompatibility.

Basic Information

Product Name	3-(Triethylsilyl)-2-Propyn-1-Ol
CAS No.	2652-46-2
Molecular Formula	C9H18OSi
Molecular Weight	170.32 g/mol
Synonyms	2-Propyn-1-ol, 3-(triethylsilyl)-; 3-(Triethylsilyl)prop-2-yn-1-ol; 3-Triethylsilyl-2-propyn-1-ol; Triethyl(3-hydroxy-1-propynyl)silane; 3-(Triethylsilyl)propargyl alcohol; (3-Hydroxyprop-1-yn-1-yl)triethylsilane; TES-Propargyl Alcohol; Triethylsilyl propargyl alcohol
EINECS	Contact for details

Quality Control

Our production of 3-(Triethylsilyl)-2-Propyn-1-Ol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to meet your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.