Description

Rac α-Amino-3,4-Dimethoxy-α-Methylbenzenepropanenitrile Hydrochloride is a high-purity chemical intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a versatile chiral building block, enabling the construction of complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs) and fine chemicals. Its reliable quality and consistent supply are critical for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in catalytic and stoichiometric asymmetric synthesis to introduce specific stereocenters.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the synthesis of compound libraries for biological screening.
• Fine Chemical Production: Serves as a precursor in the manufacture of specialty chemicals, agrochemicals, and advanced materials.
• Academic & Industrial R&D: Utilized in methodological development and process chemistry research within university and corporate laboratories.

Basic Information

Product Name	Rac α-Amino-3,4-Dimethoxy-α-Methylbenzenepropanenitrile Hydrochloride
CAS No.	2544-12-9
Molecular Formula	C₁₃H₁₉ClN₂O₂
Molecular Weight	270.76 g/mol
Synonyms	α-Amino-3,4-dimethoxy-α-methylbenzenepropanenitrile hydrochloride (racemic); 2-Amino-2-(3,4-dimethoxyphenyl)butyronitrile hydrochloride; 3,4-Dimethoxy-α-methyl-α-aminobenzene propanenitrile hydrochloride; (RS)-2-Amino-2-(3,4-dimethoxyphenyl)butyronitrile hydrochloride; α-Methyl-3,4-dimethoxyphenylalanine nitrile hydrochloride; DL-2-Amino-2-(3,4-dimethoxyphenyl)butyronitrile HCl; Racemic Verapamil Nitrile Intermediate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Rac α-Amino-3,4-Dimethoxy-α-Methylbenzenepropanenitrile Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting full specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.