Description

4-(Difluoromethylthio)Chlorobenzene is a specialized organosulfur and organofluorine building block of significant interest in advanced chemical synthesis. Its core value lies in the unique reactivity imparted by the difluoromethylthio (-SCF2H) group adjacent to a chlorinated aromatic ring, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity intermediates for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the incorporation of the difluoromethylthio moiety into drug candidates, potentially enhancing metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethylthio group can contribute to biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals that require specific fluorine-containing aromatic units.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions due to the reactive chlorine atom.
• Fluorine Chemistry Research: A valuable compound for studying the properties and reactivity of difluoromethylthioethers in academic and industrial R&D settings.

Basic Information

Product Name	4-(Difluoromethylthio)Chlorobenzene
CAS No.	2488-66-6
Molecular Formula	C7H5ClF2S
Molecular Weight	194.63 g/mol
Synonyms	1-Chloro-4-(difluoromethylthio)benzene; p-Chloro(difluoromethylthio)benzene; 4-Chlorophenyl difluoromethyl sulfide; Benzene, 1-chloro-4-[(difluoromethyl)thio]-; 2488-66-6; p-(Difluoromethylthio)chlorobenzene; 4-Chloro-α,α-difluorothioanisole
EINECS	Contact for details

Quality Control

Our production of 4-(Difluoromethylthio)Chlorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis using advanced techniques such as GC, HPLC, and NMR spectroscopy. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or an opaque secondary container until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.