Description

1,2-Dibromo-4-Fluorobenzene is a halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms, which allows for selective functionalization and the construction of complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and brominated aromatic cores for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where the fluorine atom often improves lipophilicity and target binding.
• Material Science Research: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atoms are excellent handles for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings, enabling rapid diversification of chemical space.
• Fluorine Chemistry Studies: Utilized as a model substrate for studying nucleophilic aromatic substitution (SNAr) and other reactions involving fluorinated arenes.
• Chemical Reference Standard: Employed in analytical laboratories as a standard for method development and quality control in chromatographic analysis.

Basic Information

Product Name	1,2-Dibromo-4-Fluorobenzene
CAS No.	2369-37-1
Molecular Formula	C6H3Br2F
Molecular Weight	253.89 g/mol
Synonyms	4-Fluoro-1,2-dibromobenzene; 1,2-Dibromo-4-fluorobenzene; 3,4-Dibromofluorobenzene; Benzene, 1,2-dibromo-4-fluoro-; 4-Fluorobenzene-1,2-dibromide; 1-Fluoro-2,3-dibromobenzene; NSC 403107
EINECS	Contact for details

Quality Control

Our 1,2-Dibromo-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow crystalline solid or liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.