Description

4'-Phenyl-2,2,2-trifluoroacetophenone is a high-purity trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both a phenyl and a reactive trifluoroacetyl group, making it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as ligand synthesis and the development of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for method development and exploring new fluorination reactions and heterocyclic chemistry.
• Reference Standard: Used as an analytical standard in quality control laboratories for method validation and impurity profiling.

Basic Information

Product Name	4'-Phenyl-2,2,2-trifluoroacetophenone
CAS No.	2369-31-5
Molecular Formula	C14H9F3O
Molecular Weight	250.22 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-phenylphenyl)ethanone; 4-Benzoylbiphenyl trifluoromethyl ketone; 1-(Biphenyl-4-yl)-2,2,2-trifluoroethanone; p-Phenylbenzoyl fluoride; (4-Phenylphenyl)trifluoromethyl ketone; α,α,α-Trifluoro-4-phenylacetophenone; 4'-Phenyl-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 4'-Phenyl-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.