Description

n-Acetylglutamic Acid Dimethyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for the preparation of complex peptides and modified glutamic acid analogs, offering controlled reactivity for precise molecular construction. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in medicinal chemistry and proteomics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly those targeting neurological pathways.
• Peptide Synthesis: Serves as a protected glutamic acid derivative in solid-phase and solution-phase peptide synthesis, enabling the incorporation of modified amino acids into peptide chains.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway research related to glutamate and acetylated amino acid metabolism.
• Fine Chemical Production: Intermediate for manufacturing specialized agrochemicals, dyes, and advanced materials requiring specific chiral or functionalized glutamic acid structures.
• Protecting Group Chemistry: The acetyl and ester groups provide orthogonal protection strategies, useful in multi-step synthetic sequences common in complex natural product synthesis.

Basic Information

Product Name	n-Acetylglutamic Acid Dimethyl Ester
CAS No.	2361-99-1
Molecular Formula	C9H15NO5
Molecular Weight	217.22 g/mol
Synonyms	Dimethyl N-Acetyl-L-glutamate; L-Glutamic acid, N-acetyl-, dimethyl ester; Ac-Glu(OMe)-OMe; N-Acetyl-L-glutamic acid dimethyl ester; (S)-2-Acetamidopentanedioic acid dimethyl ester; N-Acetylglutamic acid dimethyl ester; Acetylglutamic acid dimethyl ester; Dimethyl acetylglutamate
EINECS	219-107-8

Quality Control

Our n-Acetylglutamic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including chiral purity verification, assay, and impurity profiling to ensure it meets the stringent requirements for research and synthesis. Certificates of Analysis (COA) detailing purity, identity, and specific test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong bases and organic solvents as indicated by its chemical properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.