Description

1-Fluoro-2-[(trifluoromethyl)sulfonyl]benzene is a high-value fluorinated aromatic sulfone building block. This compound is critical for introducing the highly electron-withdrawing triflyl group into complex molecular architectures, enabling precise tuning of electronic and steric properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonyl and fluorine motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific electronic properties.
• Material Science: Serves as a monomer or precursor for specialty polymers, liquid crystals, and electronic materials.
• Catalyst & Ligand Development: Employed in the design of novel organocatalysts and metal-organic ligands for asymmetric synthesis.
• Chemical Research: A versatile reagent for organic synthesis, including cross-coupling reactions and as a precursor for other functionalized arenes.
• Fluorine Chemistry: Essential for studies in fluorination methodologies and the creation of molecules with enhanced metabolic stability and lipophilicity.

Basic Information

Product Name	1-Fluoro-2-[(Trifluoromethyl)Sulfonyl]Benzene
CAS No.	2358-41-0
Molecular Formula	C7H4F4O2S
Molecular Weight	228.17 g/mol
Synonyms	2-Fluorophenyl trifluoromethyl sulfone; 1-Fluoro-2-(trifluoromethanesulfonyl)benzene; α,α,α-Trifluoro-2-fluorobenzenemethanesulfonate; o-Fluorophenyl trifluoromethyl sulfone; 2-Fluoro-α,α,α-trifluorobenzenemethanesulfonate; Benzenesulfonyl fluoride, 2-fluoro-α,α,α-trifluoro-; (2-Fluorophenyl)(trifluoromethyl)sulfone
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-[(trifluoromethyl)sulfonyl]benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.