Description

5-Methyl 4-Fluoroglutamate is a specialized fluorinated glutamate derivative, a key building block in advanced organic synthesis and pharmaceutical research. This compound is valued for its unique structural features, which enable the introduction of both fluorine and a modified glutamate backbone into target molecules, influencing their biological activity and metabolic stability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and probing biochemical pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and metabolic diseases.
• Protease Inhibitor Research: Serves as a key scaffold or mimic in the development of inhibitors for glutamate-specific proteases and related enzymes.
• Agrochemical Synthesis: Used in creating advanced herbicides and plant growth regulators that leverage its fluorinated amino acid structure.
• Biochemical Tool Compound: Employed in neuroscience and cell biology research to study glutamate receptor function and amino acid metabolism.
• Peptidomimetics Development: Acts as a non-natural amino acid analog for constructing modified peptides with enhanced stability or specific binding properties.
• Radiopharmaceutical Precursor: Potential use as a precursor for fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	5-Methyl 4-Fluoroglutamate
CAS No.	2358-03-4
Molecular Formula	C6H10FNO4
Molecular Weight	179.15 g/mol
Synonyms	4-Fluoro-5-methylglutamic Acid; (2S,4R)-4-Fluoro-5-methylglutamic Acid; 5-Methyl-4-fluoroglutamic Acid; DL-5-Methyl-4-fluoroglutamate; 4-Fluoro-5-methyl-L-glutamic Acid; γ-Methyl-4-fluoroglutamate; 2-Amino-4-fluoro-5-methylpentanedioic Acid
EINECS	Contact for details

Quality Control

Every batch of 5-Methyl 4-Fluoroglutamate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA), including results for identity, purity, and specific impurities, is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.