Description

Triethyl 2-Fluoro-2-Phosphonoacetate is a high-value organophosphorus building block characterized by its unique fluorinated phosphonate ester structure. This compound is essential for introducing both fluorine and phosphonate functional groups into target molecules, enabling the synthesis of complex bioactive compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated phosphonate analogs of biologically active molecules, such as enzyme inhibitors and prodrugs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and plant growth regulators that leverage the metabolic stability imparted by the fluorine atom.
• Chemical Biology Probes: Serves as a precursor for synthesizing activity-based probes and molecular tools to study phosphonate-dependent biological processes.
• Material Science Research: Employed in the development of specialty polymers and ligands for metal-organic frameworks (MOFs) where the phosphonate group acts as a chelating agent.
• Peptidomimetics: Facilitates the creation of fluorinated phosphonate peptides, which are stable mimics of phosphate esters and useful in drug discovery.

Basic Information

Product Name	Triethyl 2-Fluoro-2-Phosphonoacetate
CAS No.	2356-16-3
Molecular Formula	C8H16FO5P
Molecular Weight	242.18 g/mol
Synonyms	2-Fluoro-2-phosphonoacetic Acid Triethyl Ester; Diethyl (Ethoxycarbonylfluoromethyl)phosphonate; (Ethoxycarbonylfluoromethyl)phosphonic Acid Diethyl Ester; Triethyl Fluorophosphonoacetate; Acetic Acid, 2-Fluoro-2-phosphono-, Triethyl Ester; Fluorophosphonoacetic Acid Triethyl Ester; 2356-16-3; EINECS 219-104-7
EINECS	219-104-7

Quality Control

Every batch of Triethyl 2-Fluoro-2-Phosphonoacetate is produced and analyzed under strict quality management protocols to ensure consistency and high purity suitable for research and scale-up applications. Our quality assurance includes identity confirmation, purity assay, and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.