Description

3-Chloro-4-Hydroxybenzonitrile is a versatile aromatic nitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl and a chloro substituent, makes it a valuable intermediate for constructing complex molecules with specific electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and plant growth regulators, leveraging its halogenated phenol structure.
• Liquid Crystal & Polymer Chemistry: Serves as a monomer or intermediate for producing high-performance polymers and liquid crystal materials for electronic displays.
• Dyestuff & Pigment Manufacturing: Acts as a building block for synthesizing azo dyes and complex organic pigments.
• Organic Synthesis & Research: A versatile reagent for constructing benzofurans, quinazolines, and other heterocyclic compounds in academic and industrial R&D.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig amination for carbon-carbon and carbon-nitrogen bond formation.

Basic Information

Product Name	3-Chloro-4-Hydroxybenzonitrile
CAS No.	2315-81-3
Molecular Formula	C7H4ClNO
Molecular Weight	153.56 g/mol
Synonyms	4-Cyano-2-chlorophenol; 2-Chloro-4-cyanophenol; 3-Chloro-4-hydroxybenzenecarbonitrile; 4-Hydroxy-3-chlorobenzonitrile; Benzonitrile, 3-chloro-4-hydroxy-; 3-Chloro-4-hydroxy-phenyl cyanide; 2-Chloro-4-hydroxybenzonitrile; 3-Chloro-4-hydroxyphenyl cyanide
EINECS	219-028-9

Quality Control

Our 3-Chloro-4-Hydroxybenzonitrile is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	145 - 149 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.