Description

Ethyl Phenylpropiolate is a specialized organic ester compound with the CAS registry number 2216-94-6. This chemical serves as a valuable intermediate and building block in advanced organic synthesis, prized for its reactive propiolate functionality. It is primarily utilized by research and development chemists, as well as production specialists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring phenylacetylene or propiolic acid derivatives.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides, leveraging its reactivity for creating novel heterocyclic compounds.
• Fine Chemical Manufacturing: Acts as a precursor for fragrances, flavors, and specialty polymers where the phenylpropiolate moiety is integral.
• Academic & Industrial Research: Employed in methodological development, catalysis studies, and material science research as a model substrate.
• Chemical Cross-coupling Reactions: Serves as an effective coupling partner in Sonogashira and other palladium-catalyzed reactions.

Basic Information

Product Name	Ethyl Phenylpropiolate
CAS No.	2216-94-6
Molecular Formula	C11H10O2
Molecular Weight	174.20 g/mol
Synonyms	Ethyl 3-phenylpropiolate; Phenylpropiolic Acid Ethyl Ester; Ethyl Phenylpropynoate; 3-Phenylpropiolic Acid Ethyl Ester; Ethyl 3-Phenyl-2-propynoate; Ethyl Benzeneacetate, 2-propynoic acid ester; Ethyl (Phenylethynyl)formate
EINECS	218-712-7

Quality Control

Our Ethyl Phenylpropiolate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including chromatography (HPLC, GC) and spectroscopic methods (IR, NMR) to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.550 - 1.560
Density (20°C)	1.05 - 1.10 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.