Description

2-[(4-Bromophenoxy)Methyl]Oxirane is a brominated aromatic glycidyl ether featuring a reactive epoxide ring and a para-brominated phenoxy moiety, enabling versatile covalent coupling in synthetic chemistry. It serves as a high-value building block for pharmaceutical intermediates, specialty polymers, and functionalized epoxy resins where controlled reactivity and halogen-directed cross-coupling are required. This compound is essential for R&D laboratories and fine chemical manufacturers engaged in drug discovery, advanced materials development, and custom synthesis of halogenated heterocycles and dendritic architectures.

Application

• Pharmaceutical intermediate for synthesizing brominated benzoxazole and benzimidazole derivatives used in kinase inhibitor scaffolds
• Monomer in the preparation of flame-retardant epoxy resins leveraging the bromine content and epoxide functionality
• Chemoselective linker in bioconjugation chemistry—epoxide ring opens selectively under mild basic conditions to attach biomolecules to bromophenol-functionalized surfaces
• Key precursor in Suzuki and Ullmann-type cross-coupling reactions for constructing biaryl ethers in agrochemical active ingredient synthesis
• Building block for photoresist components in semiconductor lithography, where the bromine atom enhances etch resistance and the epoxide enables thermal crosslinking
• Intermediate in the synthesis of chiral ligands for asymmetric catalysis, particularly after regioselective epoxide ring opening with nucleophiles

Basic Information

Product Name	2-[(4-Bromophenoxy)Methyl]Oxirane
CAS No.	2212-06-8
Molecular Formula	C9H9BrO2
Molecular Weight	229.07 g/mol
Synonyms	4-Bromophenyl glycidyl ether; 1-(4-Bromophenoxy)-2,3-epoxypropane; (Oxiran-2-ylmethoxy)-4-bromobenzene; 4-Bromophenoxy methyl oxirane; p-Bromophenyl glycidyl ether; 2-[(4-Bromophenoxy)methyl]oxirane; 4-Bromophenoxy-2,3-propylene oxide; Glycidyl 4-bromophenyl ether
EINECS	218-645-3

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to ACS Reagent Grade specifications for organic epoxides, including strict limits on residual solvents, heavy metals (≤10 ppm total), and peroxide formation. Testing includes HPLC purity verification (≥98.5%), IR spectral confirmation, and epoxide equivalent weight titration.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Due to its light-sensitive nature, exposure to ambient or UV light must be minimized during handling and storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference standard spectrum
Assay (by HPLC)	≥98.5%
Epoxide Content (by titration)	12.8–13.2% (w/w)
Residue on Ignition	≤0.1%
Water (KF)	≤0.2%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Single impurity ≤0.3%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.