Description

Methylenebismalonic Acid Diethyl Ester is a versatile and reactive diester derivative of malonic acid, serving as a key building block in organic synthesis. Its value lies in its ability to act as a bis-electrophile or a source of a stabilized carbanion, enabling the construction of complex molecular frameworks. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing a central methylene-linked dicarbonyl motif.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate malonate-derived structures.
• Organic Synthesis Building Block: Employed in Knoevenagel condensations, Michael additions, and cyclization reactions to create complex heterocycles and functionalized molecules.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers with specific thermal or mechanical properties.
• Material Science Research: Utilized in the synthesis of organic ligands for metal-organic frameworks (MOFs) and other advanced functional materials.
• Fine Chemical Production: Serves as an intermediate for dyes, pigments, and flavor/fragrance compounds requiring precise molecular architecture.

Basic Information

Product Name	Methylenebismalonic Acid Diethyl Ester
CAS No.	2121-66-6
Molecular Formula	C11H16O8
Molecular Weight	276.24 g/mol
Synonyms	Diethyl Methylenebis(malonate); Diethyl 2,2'-(Methylenebis(oxy))bis(2-oxoacetate); Diethyl (Methylenedimalonate); Propanedioic acid, 2,2'-methylenebis-, diethyl ester; Methylenebis(malonic acid diethyl ester); Ethyl Methylenebismalonate; Bis(ethoxycarbonyl)methane malonate derivative; 1,1'-(Methylenebis(oxy))bis(1-oxopropane-1,2,2-tricarboxylic acid) triethyl ester (related structure)
EINECS	218-324-6

Quality Control

Our Methylenebismalonic Acid Diethyl Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, physical characteristics, and test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.