Description

6-Fluoro-5-Trifluoromethylpyridine-3-Boronic Acid Pinacol Ester is a high-value, multi-fluorinated pyridine boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex molecules with precision. This advanced intermediate is critically needed by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. The compound, CAS NO 1971914-58-5, is designed for applications requiring high purity and reliable performance in demanding synthetic sequences.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery for CNS, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid, offering improved stability and handling for palladium-catalyzed C-C bond formation reactions.
• Library Synthesis for Medicinal Chemistry: Enables the rapid parallel synthesis of diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	6-Fluoro-5-Trifluoromethylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1971914-58-5
Molecular Formula	C₁₂H₁₄BF₄NO₂
Molecular Weight	291.05 g/mol
Synonyms	5-Trifluoromethyl-6-fluoropyridine-3-boronic acid pinacol ester; 3-Pyridineboronic acid, 6-fluoro-5-(trifluoromethyl)-, 1,1-dimethylethyl ester; 6-Fluoro-5-(trifluoromethyl)pyridin-3-ylboronic acid pinacol ester; (6-Fluoro-5-(trifluoromethyl)pyridin-3-yl)boronic acid pinacol ester; Pinacol 6-Fluoro-5-trifluoromethylpyridine-3-boronate; Boronic acid, B-[6-fluoro-5-(trifluoromethyl)-3-pyridinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container should be kept tightly sealed in a desiccated environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.