Description

(2E)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Prop-2-Enoic Acid (Wx652059) is a high-purity, advanced pharmaceutical intermediate featuring a strategically positioned boronic ester and a cinnamic acid moiety. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly for targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for constructing biaryl and conjugated systems.
• Agrochemical Research: Used in developing new active ingredients for crop protection with improved efficacy.
• Material Science: Building block for organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology: Utilized in probe and linker synthesis for studying biological processes.
• Academic & R&D: A valuable reagent for methodological development and novel compound library synthesis in research laboratories.

Basic Information

Product Name	(2E)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Prop-2-Enoic Acid (Wx652059)
CAS No.	1967825-39-3
Molecular Formula	C15H19BO4
Molecular Weight	274.12 g/mol
Synonyms	(E)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acrylic acid; 3-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-propenoic acid, (2E)-; Wx652059; trans-3-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acrylic acid; Boronic acid, B-[3-[(1E)-2-carboxyethenyl]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 3-(3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)prop-2-enoic acid
EINECS	Contact for details

Quality Control

Our (2E)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Prop-2-Enoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.