Description

1-(Trifluoromethyl)-2-Azabicyclo[2.1.1]Hexane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique bridged bicyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking to develop next-generation drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs) with potential neurological activity.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation platforms.
• CNS Drug Discovery: Applied in the research of therapeutics for disorders of the central nervous system due to its ability to influence blood-brain barrier permeability.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Chemical Biology Probes: Used to create tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	1-(Trifluoromethyl)-2-Azabicyclo[2.1.1]Hexane Hydrochloride
CAS No.	1955505-59-5
Molecular Formula	C7H9F3N·HCl
Molecular Weight	203.61 g/mol (Free base: 167.15 g/mol)
Synonyms	1-(Trifluoromethyl)-2-azabicyclo[2.1.1]hexane HCl; 2-Azabicyclo[2.1.1]hexane, 1-(trifluoromethyl)-, hydrochloride; 1-(Trifluoromethyl)-2-azabicyclo[2.1.1]hexane hydrochloride; 1-(Trifluoromethyl)-2-azabicyclo[2.1.1]hexane, HCl salt; 1955505-59-5; 2-Azabicyclo[2.1.1]hexane, 1-(trifluoromethyl)-, monohydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethyl)-2-Azabicyclo[2.1.1]Hexane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support custom synthesis to meet specific purity or packaging requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.