Description

trans-2-(3-Chlorophenyl)Cyclopropaneboronic Acid Pinacol Ester is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its stability and reactivity, making it an essential reagent for the Suzuki-Miyaura cross-coupling reaction, a cornerstone method for forming carbon-carbon bonds. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing a substituted cyclopropane or biphenyl moiety.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific chlorophenyl-cyclopropyl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, via cross-coupling to create conjugated polymers.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	trans-2-(3-Chlorophenyl)Cyclopropaneboronic Acid Pinacol Ester
CAS No.	1953178-19-2
Molecular Formula	C15H20BClO2
Molecular Weight	278.58 g/mol
Synonyms	trans-2-(3-Chlorophenyl)cyclopropane-1-boronic acid pinacol ester; (1R,2S)-2-(3-Chlorophenyl)cyclopropylboronic acid pinacol ester; (1S,2R)-2-(3-Chlorophenyl)cyclopropylboronic acid pinacol ester; trans-2-(m-Chlorophenyl)cyclopropylboronic acid pinacol ester; 3-Chlorophenylcyclopropylboronic acid pinacol ester; Boronic acid, B-[trans-2-(3-chlorophenyl)cyclopropyl]-, 2,2-dimethyl-1,3-propanediyl ester; B-[trans-2-(3-Chlorophenyl)cyclopropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our trans-2-(3-Chlorophenyl)Cyclopropaneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Isomeric Purity (trans)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.