Description

3-((tert-Butyldiphenylsilyl)Oxy)-2,2-Difluoropropan-1-Ol is a high-value, protected fluorinated alcohol intermediate designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists requiring precise control over stereochemistry and functional group manipulation in sensitive environments. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where the introduction of fluorine atoms and protected hydroxyl groups is essential.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where fluorine substitution enhances biological activity and environmental stability.
• Material Science: Serves as a monomer or precursor for fluorinated polymers and specialty coatings with unique surface properties.
• Organic Synthesis: A versatile reagent for introducing the 2,2-difluoro-1-hydroxypropyl moiety in complex molecule construction, leveraging the TBDPS protecting group for orthogonal deprotection strategies.
• Peptide & Nucleotide Chemistry: Employed in the modification of biomolecules to alter their pharmacokinetic profiles or to serve as a synthetic handle for conjugation.
• Ligand & Catalyst Development: Useful in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	3-((tert-Butyldiphenylsilyl)Oxy)-2,2-Difluoropropan-1-Ol
CAS No.	1953133-33-9
Molecular Formula	C19H24F2O2Si
Molecular Weight	350.48 g/mol
Synonyms	2,2-Difluoro-3-((tert-butyldiphenylsilyl)oxy)-1-propanol; 1-Propanol, 2,2-difluoro-3-[(1,1-dimethylethyl)diphenylsilyl]oxy]-; 3-(TBDPSO)-2,2-difluoropropan-1-ol; tert-Butyl(2,2-difluoro-3-hydroxypropoxy)diphenylsilane; TBDPS-protected 2,2-difluoropropanol; 2,2-Difluoro-3-hydroxypropyl tert-butyldiphenylsilyl ether
EINECS	Contact for details

Quality Control

Our 3-((tert-Butyldiphenylsilyl)Oxy)-2,2-Difluoropropan-1-Ol is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to support your R&D and cGMP-compliant processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.