Description

3-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is a high-value, multi-functional heterocyclic building block that integrates an indazole core with a boronic ester pinacol protecting group. This compound matters as a critical intermediate for modern cross-coupling reactions, enabling the efficient synthesis of complex molecules for pharmaceutical and agrochemical research. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for constructing novel drug candidates, particularly kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel indazole-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and optimization of drug candidates, especially for oncology and anti-inflammatory targets.
• Kinase Inhibitor Development: Serves as a core scaffold for creating potent and selective kinase inhibitors due to the indazole pharmacophore.
• Agrochemical Synthesis: Employed in the research and development of new herbicides and fungicides with novel modes of action.
• Material Science: Potential building block for organic electronic materials and metal-organic frameworks (MOFs) due to its conjugated system and boronate functionality.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions.

Basic Information

Product Name	3-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	1939174-70-5
Molecular Formula	C₁₃H₁₆BClN₂O₂
Molecular Weight	278.54 g/mol
Synonyms	3-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 3-Chloro-6-(pinacolboron)-1H-indazole; 6-Boronic acid, 3-chloro-1H-indazole-6-, pinacol ester; 3-Chloro-1H-indazole-6-boronic acid pinacol ester; 3-Chloro-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1939174-70-5; 3-Chloro-6-pinacolatoboryl-1H-indazole
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.