Description

Ethyl 3-Fluorobicyclo[1.1.1]Pentane-1-Carboxylate is a high-value, synthetically versatile fluorinated building block characterized by its unique strained bicyclo[1.1.1]pentane (BCP) scaffold. This compound is engineered to serve as a critical intermediate in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules with improved metabolic stability and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery and the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the rigid, three-dimensional BCP bioisostere into drug candidates, potentially enhancing potency and pharmacokinetic profiles.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and lead optimization programs to explore novel chemical space and improve drug-like properties.
• Agrochemical Synthesis: Serves as a building block for developing new generation pesticides and herbicides with novel modes of action.
• Material Science: Potential precursor for creating fluorinated polymers or advanced organic frameworks with specific electronic or structural characteristics.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and APIs.

Basic Information

Product Name	Ethyl 3-Fluorobicyclo[1.1.1]Pentane-1-Carboxylate
CAS No.	1935130-91-8
Molecular Formula	C8H11FO2
Molecular Weight	158.17 g/mol
Synonyms	3-Fluorobicyclo[1.1.1]pentane-1-carboxylic acid ethyl ester; Ethyl 3-fluorobicyclo[1.1.1]pentane-1-carboxylate; 1-Carbethoxy-3-fluorobicyclo[1.1.1]pentane; BCP-Fluoride Ester; 3-Fluoro-BCP-ethyl ester; Fluorinated Bicyclopentane Ester; [1.1.1]Propellane, 3-fluoro-1-carboxyethyl-
EINECS	Contact for details

Quality Control

Our Ethyl 3-Fluorobicyclo[1.1.1]Pentane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including NMR, HPLC, GC-MS, and IR spectroscopy to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.