Description

3-Azetidineacetonitrile, 1-(Ethylsulfonyl)-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]- is a high-value, multi-functional chemical building block that integrates an azetidine core with a pyrazole-boronic ester pinacol ester. This compound matters as a key synthon in modern pharmaceutical and agrochemical research, enabling efficient cross-coupling reactions like Suzuki-Miyaura for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small molecule therapeutic programs.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester functional group makes it an essential partner for palladium-catalyzed C-C bond formation with aryl/heteroaryl halides.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chelating ligands and organometallic catalysts.
• Material Science: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.

Basic Information

Product Name	3-Azetidineacetonitrile, 1-(Ethylsulfonyl)-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-
CAS No.	1919837-50-5
Molecular Formula	C16H26BN3O4S
Molecular Weight	367.27 g/mol
Synonyms	1-(Ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-3-acetonitrile; 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-1-(ethylsulfonyl)azetidine-3-acetonitrile; 1-(Ethylsulfonyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-3-acetonitrile; Azetidine-3-acetonitrile, 1-(ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-; BRN 1919837-50-5
EINECS	Contact for details

Quality Control

Our 3-Azetidineacetonitrile derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.