Description

7,7-Difluorobicyclo[4.1.0]Heptane-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique strained bicyclic structure with strategic fluorine substitution. This compound is valued for its role in modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and membrane permeability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the difluorocyclopropane moiety can influence biological activity and environmental fate.
• Material Science Precursor: Serves as a specialty monomer or cross-linking agent in the development of advanced polymers with tailored thermal and chemical resistance.
• Fluorine Chemistry & SAR Studies: An essential reagent for structure-activity relationship (SAR) studies, enabling the introduction of fluorine atoms to optimize potency and pharmacokinetic profiles.
• Academic & Industrial R&D: Employed in synthetic organic chemistry research for methodology development and the construction of complex, fluorinated molecular architectures.

Basic Information

Product Name	7,7-Difluorobicyclo[4.1.0]Heptane-3-Carboxylic Acid
CAS No.	1909327-73-6
Molecular Formula	C8H10F2O2
Molecular Weight	176.16 g/mol
Synonyms	3-Bicyclo[4.1.0]heptane-3-carboxylic acid, 7,7-difluoro-; 7,7-Difluorobicyclo[4.1.0]heptane-3-carboxylic acid; 7,7-Difluoro-3-carboxybicyclo[4.1.0]heptane; 3-Carboxy-7,7-difluorobicyclo[4.1.0]heptane; 7,7-Difluoro-3-bicyclo[4.1.0]heptanecarboxylic acid; Difluorinated Norcarane-3-carboxylic Acid; 7,7-Difluoronorcarane-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 7,7-Difluorobicyclo[4.1.0]Heptane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.