Description

1-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in the synthesis of small molecule drug candidates targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for constructing biaryl and heterobiaryl structures central to many drug molecules.
• Medicinal Chemistry Research: Enables rapid analog synthesis and structure-activity relationship (SAR) studies in drug discovery programs.
• Chemical Biology Probes: Used in the development of chemical probes for target identification and validation in biological systems.
• Agrochemical Synthesis: Potential intermediate in the research and development of novel crop protection agents.
• Material Science Research: May be employed in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine
CAS No.	1909308-00-4
Molecular Formula	C13H24BNO2
Molecular Weight	237.15 g/mol
Synonyms	1-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 1-Ethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-ethyl-1,2,3,6-tetrahydropyridine; 1-Ethyl-1,2,3,6-tetrahydropyridine-5-boronic acid pinacol ester; 1-Ethyl-5-(pinacolboronato)-1,2,3,6-tetrahydropyridine; 1-Ethyl-5-(pinacolatoboryl)-1,2,3,6-tetrahydropyridine; 1-Ethyl-5-(pinacol boronate)-1,2,3,6-tetrahydropyridine; 1-Ethyl-5-(pinacol boronic ester)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our 1-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.