Description

Benzene, 1-Bromo-2-(2,2-Difluorocyclopropyl)- is a specialized halogenated benzene derivative featuring a unique difluorocyclopropyl substituent, making it a valuable building block in advanced organic synthesis. This compound is engineered to serve as a key intermediate for the development of novel fluorinated molecules, which are critical in modern pharmaceuticals and agrochemicals. It is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated cyclopropane motifs into their target compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the difluorocyclopropyl group can enhance biological activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers and advanced materials with tailored surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for the preparation of novel ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Exploration: A key substrate for studying structure-activity relationships (SAR) and the effects of gem-difluorocyclopropane rings on molecular conformation and reactivity.
• Custom Synthesis and Contract Manufacturing: Supplied to custom synthesis organizations (CSOs) and CDMOs for client-specific molecule construction and scale-up projects.

Basic Information

Product Name	Benzene, 1-Bromo-2-(2,2-Difluorocyclopropyl)-
CAS No.	1897571-62-8
Molecular Formula	C9H7BrF2
Molecular Weight	233.05 g/mol
Synonyms	1-Bromo-2-(2,2-difluorocyclopropyl)benzene; 2-Bromo-1-(2,2-difluorocyclopropyl)benzene; o-Bromo(2,2-difluorocyclopropyl)benzene; (2-Bromophenyl)(2,2-difluorocyclopropane); Benzene, bromo-(2,2-difluorocyclopropyl)-; 1897571-62-8; 1-Bromo-2-(2,2-difluorocyclopropyl)benzene
EINECS	Contact for details

Quality Control

Our Benzene, 1-Bromo-2-(2,2-Difluorocyclopropyl)- is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality ensures the material is suitable for demanding applications in pharmaceutical and agrochemical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential decomposition. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.