Description

1,1,1-Trifluoroethyl-Peg4-Aminooxy is a specialized bifunctional PEG linker featuring an aminooxy group and a trifluoroethyl terminus, designed for advanced bioconjugation and chemical synthesis. This compound is critical for creating stable, site-specific linkages in the development of pharmaceuticals, diagnostics, and novel biomaterials. It is primarily utilized by research scientists and process development teams in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, functionalized linkers for their projects.

Application

• Bioconjugation Reagent: For the site-specific coupling of aldehydes or ketones to biomolecules like proteins, antibodies, and peptides.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key building block in the synthesis of linkers for connecting cytotoxic payloads to monoclonal antibodies.
• Polymer Modification: Used to introduce functional aminooxy groups into polymer backbones for subsequent chemical functionalization.
• Surface Immobilization: Enables the covalent attachment of biomolecules onto sensor chips, nanoparticles, and other solid supports for diagnostic assays.
• Cross-linking Agent: Facilitates the formation of stable oxime bonds between molecules in material science and hydrogel formation.
• Proteomics Research: A tool for chemical proteomics, including activity-based protein profiling and labeling studies.
• Fluorine Tagging: The trifluoroethyl group can serve as a handle for 19F NMR spectroscopy or to modulate the physicochemical properties of the conjugate.

Basic Information

Product Name	1,1,1-Trifluoroethyl-Peg4-Aminooxy
CAS No.	1895922-78-7
Molecular Formula	C15H28F3N2O6
Molecular Weight	389.39 g/mol
Synonyms	1,1,1-Trifluoro-2-[2-[2-[2-(2-Aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethane; 2,2,2-Trifluoroethyl-PEG4-aminooxy; Aminooxy-PEG4-CH2CF3; Trifluoroethyl-PEG4-ONH2; O-(2-Aminooxyethyl)-O'-(2,2,2-trifluoroethyl)tetraethylene glycol; 2,2,2-Trifluoroethyl tetraethylene glycol aminooxy ether; Amino-PEG4-trifluoroethyl ether, aminooxy form; TFE-PEG4-ONH2
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoroethyl-Peg4-Aminooxy is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.