Description

2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing trifluoromethylpyridine motifs, which are prevalent in drug discovery for their metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the pyridine-boronate core allows for the introduction of diverse aromatic systems to optimize biological activity.
• Material Science Research: Building block for constructing organic electronic materials, such as ligands for OLEDs (Organic Light-Emitting Diodes) and charge-transport materials, leveraging its electron-deficient pyridine ring.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes, where the boronate ester acts as a handle for further functionalization.
• Cross-Coupling Chemistry: A versatile reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to create biaryl and heterobiaryl structures central to many functional molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity boronic ester intermediates.

Basic Information

Product Name	2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine
CAS No.	1888460-27-2
Molecular Formula	C13H17BF3NO2
Molecular Weight	287.09 g/mol
Synonyms	3-(Trifluoromethyl)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Methyl-3-trifluoromethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-3-(trifluoromethyl)pyridine; Pinacol ester of [3-(Trifluoromethyl)-2-methylpyridin-5-yl]boronic acid; [3-(Trifluoromethyl)-2-methylpyridin-5-yl]boronic acid pinacol ester; 2-Methyl-3-trifluoromethylpyridine-5-boronic acid pinacol ester; CAS 1888460-27-2
EINECS	Contact for details

Quality Control

Our 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee supply reliability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.