Description

4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde is a versatile and high-value boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl frameworks. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable building blocks for drug discovery, ligand synthesis, and functional polymer development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or phenolic motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic architectures.
• Material Science: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	4-Hydroxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde
CAS No.	1883607-86-0
Molecular Formula	C13H17BO4
Molecular Weight	248.09 g/mol
Synonyms	2-Formyl-5-hydroxyphenylboronic acid pinacol ester; 5-Hydroxy-2-formylphenylboronic acid pinacol ester; 4-Hydroxy-2-borono-benzaldehyde pinacol ester; (4-Hydroxy-2-formylphenyl)boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-hydroxybenzaldehyde; 4-Hydroxy-2-(pinacolatoboryl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.