Description

4,4-Difluoropiperidin-3-Yl Acetate Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific difluorinated piperidine scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in areas requiring fluorinated motifs to modulate pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms, enhancing metabolic stability and bioavailability of lead compounds.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing routes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies involving fluorinated heterocycles.

Basic Information

Product Name	4,4-Difluoropiperidin-3-Yl Acetate Hydrochloride
CAS No.	1881331-81-2
Molecular Formula	C7H12F2NO2 • HCl
Molecular Weight	215.63 (Free base) / 252.09 (HCl salt)
Synonyms	3-Acetoxy-4,4-difluoropiperidine hydrochloride; 4,4-Difluoro-3-piperidinol acetate hydrochloride; 4,4-Difluoropiperidin-3-ol acetate hydrochloride; 3-Piperidinol, 4,4-difluoro-, acetate, hydrochloride; Acetic acid 4,4-difluoropiperidin-3-yl ester hydrochloride; 1881331-81-2; 4,4-Difluoro-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester acetate (related precursor)
EINECS	Contact for details

Quality Control

Our 4,4-Difluoropiperidin-3-Yl Acetate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.