Description

Benzene, 1-Bromo-2-Chloro-3-Nitro-5-(Trifluoromethyl)- is a highly functionalized, multi-substituted benzene derivative that serves as a critical building block in advanced organic synthesis. Its unique combination of halogen, nitro, and trifluoromethyl groups makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the nitro and trifluoromethyl groups.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing advanced, light-fast azo dyes and complex organic pigments.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for selective palladium-catalyzed coupling reactions (e.g., Suzuki, Heck).
• Fluorine Chemistry: The trifluoromethyl group provides a source of fluorine for further derivatization, important in medicinal chemistry to modulate lipophilicity and metabolic stability.

Basic Information

Product Name	Benzene, 1-Bromo-2-Chloro-3-Nitro-5-(Trifluoromethyl)-
CAS No.	1881331-27-6
Molecular Formula	C7H2BrClF3NO2
Molecular Weight	304.45 g/mol
Synonyms	1-Bromo-2-chloro-3-nitro-5-(trifluoromethyl)benzene; 2-Chloro-1-bromo-3-nitro-5-(trifluoromethyl)benzene; 3-Nitro-5-(trifluoromethyl)-1-bromo-2-chlorobenzene; Benzene, bromochloro(trifluoromethyl)nitro-; (Trifluoromethyl)nitrobromochlorobenzene; BCTNB (abbreviation); 5-(Trifluoromethyl)-2-chloro-1-bromo-3-nitrobenzene; 1-Bromo-2-chloro-3-nitro-α,α,α-trifluoro-p-xylene (historical)
EINECS	Contact for details

Quality Control

Our production of Benzene, 1-Bromo-2-Chloro-3-Nitro-5-(Trifluoromethyl)- adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with ISO 9001 standards and meets the exacting requirements of R&D and scale-up manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from strong acids/bases and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.