Description

2-(Benzyloxy)-5-Bromo-1-Chloro-3-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated benzene core.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated and halogenated aromatic components in electronic display and lighting materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Functional Dye & Pigment Development: Employed in the synthesis of specialized dyes and pigments where halogen and benzyloxy groups modify light absorption and stability properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	2-(Benzyloxy)-5-Bromo-1-Chloro-3-Fluorobenzene
CAS No.	1881293-72-6
Molecular Formula	C13H9BrClFO
Molecular Weight	315.56 g/mol
Synonyms	1-Chloro-3-fluoro-5-(phenylmethoxy)-2-bromobenzene; 5-Bromo-1-chloro-3-fluoro-2-(phenylmethoxy)benzene; 2-Bromo-1-chloro-3-fluoro-5-(benzyloxy)benzene; 1-Chloro-3-fluoro-2-(benzyloxy)-5-bromobenzene; Benzene, 2-(benzyloxy)-5-bromo-1-chloro-3-fluoro-; 5-Bromo-2-(benzyloxy)-1-chloro-3-fluorobenzene
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-5-Bromo-1-Chloro-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.