Description

Methyl 4-Bromo-2,3-Difluoro-5-Iodobenzoate (Wx191886) is a high-purity, multi-halogenated benzoate ester building block, essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which provides multiple reactive sites for selective functionalization in complex molecule construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates. Its precise structure enables the exploration of new chemical space in drug discovery and material science programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Stille, Sonogashira) due to the presence of bromo and iodo substituents.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	Methyl 4-Bromo-2,3-Difluoro-5-Iodobenzoate (Wx191886)
CAS No.	1878217-46-9
Molecular Formula	C8H4BrF2IO2
Molecular Weight	376.92 g/mol
Synonyms	Benzoic acid, 4-bromo-2,3-difluoro-5-iodo-, methyl ester; Methyl 4-bromo-2,3-difluoro-5-iodobenzoate; 4-Bromo-2,3-difluoro-5-iodobenzoic acid methyl ester; WX-191886; Wx191886; MFCD31812862; 1878217-46-9; SCHEMBL23305577
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Bromo-2,3-Difluoro-5-Iodobenzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive R&D and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (HPLC), identity confirmation (NMR, IR), and impurity profiles. Our quality commitment supports compliance with cGMP and ISO 9001 standards for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert conditions when appropriate to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.