Description

1-Fluoro-Cyclopropanecarboxylic Acid Methyl Ester is a high-value fluorinated cyclopropane building block essential for advanced organic synthesis. This compound is critical for introducing the metabolically stable and sterically constrained cyclopropane moiety into target molecules, which can significantly alter their biological activity and physicochemical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorocyclopropane group can enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a monomer or building block for developing specialty polymers and advanced materials with unique electronic or surface properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to explore the effects of fluorination and ring strain on potency and selectivity.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study enzyme mechanisms and biological pathways.
• Cross-Coupling Reactions: The ester group can be hydrolyzed to the corresponding acid, which can then be used in various cross-coupling reactions to create complex molecular architectures.

Basic Information

Product Name	1-Fluoro-Cyclopropanecarboxylic Acid Methyl Ester
CAS No.	1877341-77-9
Molecular Formula	C5H7FO2
Molecular Weight	118.10 g/mol
Synonyms	Methyl 1-Fluorocyclopropanecarboxylate; 1-Fluorocyclopropanecarboxylic Acid Methyl Ester; Methyl 1-Fluorocyclopropane-1-carboxylate; Cyclopropanecarboxylic acid, 1-fluoro-, methyl ester; 1-Fluorocyclopropane-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Fluoro-Cyclopropanecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.