Description

3-(Trifluoromethyl)Bicyclo[1.1.1]Pentane-1-Carboxamide is a high-value, synthetically challenging trifluoromethylated bicyclic building block. This compound matters for its unique three-dimensional structure and the introduction of a metabolically stable trifluoromethyl group, which are critical for modulating the physicochemical properties of advanced molecules. It is primarily needed by medicinal chemistry and process R&D teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in fragment-based drug discovery and for creating bioisosteres of tert-butyl or aromatic groups.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the bicyclo[1.1.1]pentane (BCP) scaffold can improve stability and bioavailability.
• Material Science Precursor: Serves as a specialty monomer or cross-linking agent for advanced polymers with tailored thermal and chemical resistance properties.
• Chemical Biology Probe: Employed as a rigid, sp3-rich scaffold in chemical probe design to study protein function and protein-protein interactions.
• Ligand Development: Useful for creating novel ligands in catalysis, where the BCP core offers unique steric and electronic environments.

Basic Information

Product Name	3-(Trifluoromethyl)Bicyclo[1.1.1]Pentane-1-Carboxamide
CAS No.	1877049-55-2
Molecular Formula	C7H8F3NO
Molecular Weight	179.14 g/mol
Synonyms	3-(Trifluoromethyl)bicyclo[1.1.1]pentane-1-carboxamide; 3-(Trifluoromethyl)-1-bicyclo[1.1.1]pentanecarboxamide; BCP-CF3-Carboxamide; 1-Carbamoylbicyclo[1.1.1]pentane-3-trifluoromethyl; 3-Trifluoromethyl-BCP-amide; [1.1.1]Propellane-3-carboxamide, 1-(trifluoromethyl)-; 1-Aminocarbonyl-3-(trifluoromethyl)bicyclo[1.1.1]pentane
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Bicyclo[1.1.1]Pentane-1-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We support development projects with custom purity grades and specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95% (Standard Grade)
Purity (HPLC)	≥ 98% (High Purity Grade)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.