Description

1-(3-Oxetanyl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block designed for advanced organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly in the construction of complex heterocyclic scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and the pyrazole-oxetane moiety.
• Pharmaceutical Intermediate: Serves as a versatile building block in the synthesis of potential drug candidates, especially those targeting kinase inhibition or requiring oxetane bioisosteres.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science Precursor: Can be incorporated into organic frameworks or polymers to modify electronic or physical properties.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.
• Ligand Synthesis: Potential precursor for creating specialized ligands used in catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-(3-Oxetanyl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester
CAS No.	1876473-44-7
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	1-(Oxetan-3-yl)-1H-pyrazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(oxetan-3-yl)-1H-pyrazole; 1-(Oxetan-3-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(3-Oxetanyl)-1H-pyrazole-5-boronic acid, pinacol ester; 1-(Oxetane-3-yl)-1H-pyrazole-5-boronic acid pinacol ester; 1-(Oxetan-3-yl)-1H-pyrazol-5-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(3-Oxetanyl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are fully characterized (NMR, HPLC, MS) to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. The compound is moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Assay (NMR)	≥90%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.