Description

2-{4-[(4-Chlorophenyl)Methyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient and selective carbon-carbon bond formation, a cornerstone reaction for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for palladium-catalyzed cross-coupling to create biaryl structures, a common motif in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the research and scale-up production of novel therapeutic compounds, including kinase inhibitors and other small molecule drugs.
• Agrochemical Development: Serves as a precursor in the synthesis of advanced herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, such as those used in OLEDs and semiconductors.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-{4-[(4-Chlorophenyl)Methyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1870804-20-8
Molecular Formula	C19H22BClO2
Molecular Weight	328.64 g/mol
Synonyms	4-(4-Chlorobenzyl)phenylboronic acid pinacol ester; [4-(4-Chlorobenzyl)phenyl]boronic acid pinacol ester; 2-[4-[(4-Chlorophenyl)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(4-Chlorobenzyl)phenyl)boronic acid pinacol ester; 4-(p-Chlorobenzyl)phenylboronic acid pinacol ester; PINACOL [4-(4-CHLOROBENZYL)PHENYL]BORONATE; 4-(4-Chlorobenzyl)benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-{4-[(4-Chlorophenyl)Methyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC). Each lot undergoes comprehensive analytical testing including NMR (1H, 13C, 11B) for structural confirmation and HPLC for purity and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent hydrolysis and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.