Description

Methyl 5-Amino-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is a high-value, multifunctional chemical building block that combines a picolinate ester with a protected boronic acid pinacol ester and an amino group. This compound matters because it serves as a critical intermediate in modern synthetic chemistry, enabling the construction of complex molecules through versatile cross-coupling and functionalization reactions. Pharmaceutical, agrochemical, and advanced materials researchers need this reagent for developing active ingredients, ligands, and functional polymers, where its unique trifunctional scaffold allows for precise molecular design and diversification.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety is a stable, reactive handle for palladium-catalyzed cross-coupling with aryl/heteroaryl halides, enabling efficient biaryl bond formation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Ligand and Catalyst Development: The amino and ester groups provide sites for further modification to create novel chelating ligands for catalysis or metal-organic frameworks (MOFs).
• Material Science Research: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Utilized to create tagged molecules or activity-based probes for studying biological pathways and target engagement.

Basic Information

Product Name	Methyl 5-Amino-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate
CAS No.	1859083-82-1
Molecular Formula	C13H19BN2O4
Molecular Weight	278.11 g/mol
Synonyms	Methyl 5-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate; 5-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic Acid Methyl Ester; Methyl 5-Amino-4-(pinacolatoboron)picolinate; 4-Borono-5-aminopicolinic Acid Methyl Ester Pinacol Ester; 2-Pyridinecarboxylic Acid, 5-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, Methyl Ester; 1859083-82-1; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-aminopicolinic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Amino-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under an inert atmosphere for prolonged operations to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.